I-MyOme ibonise idatha evela kwipowusta kwinkomfa ye-American Society of Human Genetics (ASHG) egxininise kwi-polygenic risk score (caIRS), edibanisa i-genetics kunye nemingcipheko yesiqhelo yeklinikhi ukuze kuphuculwe ukuchongwa kwabantu abasemngciphekweni ophezulu kwi-coronary artery disease. (CAD) kubantu abahlukeneyo.
Iziphumo zibonise ukuba i-caIRS ichonge ngokuchanekileyo ngakumbi abantu abasengozini ephezulu yokuphuhlisa isifo se-coronary artery, ngakumbi phakathi komda okanye kuluhlu oluphakathi lwengozi yonyango kunye nabantu baseMzantsi Asia.
Ngokwemveli, uninzi lwezixhobo zovavanyo lomngcipheko we-CAD kunye neemvavanyo ziye zaqinisekiswa kubantu abancinci, ngokutsho kuka-Akash Kumar, MD, PhD, igosa eliyintloko lezonyango kunye nesayensi leMyOme.Isixhobo esisetyenziswa ngokuqhelekileyo, i-Atherosclerotic Cardiovascular Disease (ASCVD) Pooled Cohort Equation (PCE), ixhomekeke kumanyathelo asemgangathweni afana namanqanaba e-cholesterol kunye nesimo seswekile ukuqikelela ingozi ye-CAD ye-10 kunye nezigqibo zesikhokelo malunga nokuqaliswa kwonyango lwe-statin, waphawula uKumar. .
Idibanisa izigidi zeenguqu zemfuzo
Amanqaku e-Polygenic risk scores (PRS), ahlanganisa izigidi zeenguqu zofuzo zobukhulu obuncinci besiphumo kwinqaku elinye, zinika amandla okuphucula ukuchaneka kwezixhobo zovavanyo lwengozi yeklinikhi," waqhubeka uKumar.I-MyOme iphuhlise kwaye yaqinisekisa inqaku lomngcipheko elidibeneyo elidibanisa i-PRS ye-cross-ancestry kunye ne-caIRS.
Iziphumo eziphambili ezivela kwinkcazo zibonise ukuba i-caIRS iphucule kakhulu ucalucalulo xa kuthelekiswa ne-PCE kuwo onke amaqela okuqinisekisa kunye nookhokho abavavanyiweyo.I-CaIRS iphinde yachonga ukuya kutsho kwi-27 yeziganeko ezongezelelweyo ze-CAD kumntu ngamnye we-1,000 kwiqela lomda / eliphakathi le-PCE.Ukongeza, abantu baseMzantsi Asia babonise ukwanda okukhulu kocalucalulo.
“Inqaku lomngcipheko elihlanganisiweyo le-MyOme linokuphucula uthintelo kunye nolawulo lwezifo kukhathalelo oluphambili ngokuchonga abantu abasengozini ephezulu yokuphuhla kweCAD, ebebenokuthi ngenye indlela baphoswe,” utshilo uKumar."Ngokuqaphelekayo, i-caIRS ibisebenza kakhulu ekuchongeni abantu baseMzantsi Asia abasemngciphekweni we-CAD, ebaluleke kakhulu ngenxa yezinga labo lokufa eliphantse libe kabini xa kuthelekiswa nabantu baseYurophu."
Inkcazo yeposta ye-Myome yayinesihloko esithi "Ukudityaniswa kwePolygenic Risk Scores kunye neClinical Factors Iphucula i-10-year Risk Prediction of Coronary Artery Disease."
Ixesha lokuposa: Nov-10-2023