I-Platelet-derived growth factor analyzers SEB-C100
Intshayelelo yemveliso
I-Platelet Derived Growth Factor Analyzer sisixhobo sokuvavanya kunye nokuhlalutya okusekwe kwindlela yokuvavanya ekhethekileyo eyenziwa yinkampani yethu.I-analyzer ibona i-platelet-derived growth factor, i-protein marker ethile kumchamo womntu oveliswayo xa kwenzeka i-coronary artery stenosis.Uhlalutyo lunokugqitywa kwimizuzu embalwa ngokusebenzisa i-1ml yomchamo kuphela.I-analyzer inokugqiba ukuba i-coronary arteries ine-stenosis kunye ne-degree of stenosis ukwenzela ukunika isalathiso sovavanyo olongezelelweyo.Indlela yokubona kunye nokuhlalutya ye-platelet-derived growth factor analyzer yindlela yokuqala yokubona engeyiyo i-invasive, engadingi inaliti kunye neziyobisi ezincedisayo, ukuphelisa ingxaki yokuba abantu abachasene ne-iodine equkethe i-iodine-contrast agents abakwazi ukwenza i-CT kunye nezinye i-coronary. i-angiography yomthambo.I-analyzer ineenzuzo zexabiso eliphantsi lokuvavanya, uluhlu olubanzi lwesicelo, isicelo esilula, isivinini sokuvavanya ngokukhawuleza, njl., kwaye luhlobo olutsha lwe-coronary artery stenosis ukufumanisa kwangaphambili kunye nesixhobo sokuhlola.
I-analyzer ineenzuzo ezilandelayo:
1. Ukukhawuleza: Faka umchamo kwisixhobo sokubona kwaye ulinde nje imizuzu embalwa
2. Uncedo: Uvavanyo alufumaneki ezibhedlele kuphela.Zisenokwenziwa nakumaziko okuhlolwa kwezonyango, kumakhaya abongikazi okanye kumakhaya entlalontle yoluntu
3. Intuthuzelo: Kuphela i-1ml yomchamo efunekayo njengesampulu, akukho gazi litsalwayo, akukho mayeza, akukho naliti ezichaseneyo, akukho nkxalabo malunga nokungaguquki komzimba.
4. Intelligence: Ukuhlolwa okuzenzekelayo ngokupheleleyo, ukusebenza ngokungalindelekanga
5. Ukufakwa ngokulula: Ubungakanani obuncinci, bunokufakwa kwaye busetyenziswe kunye nesiqingatha setafile
6. Ulondolozo olulula: Ibeka iliso ngokuzenzekelayo kwaye ibonise isimo sokusetyenziswa ukwenzela ukutshintshwa okulula
Umgaqo wemveliso
I-Raman spectroscopy isebenzisa ukukhanya okusasazeka ukuhlalutya ngokukhawuleza ubume bemolekyuli.Obu buchule busekelwe kumgaqo wokuba xa ukukhanya kukhanyisa imolekyuli, kubakho ukungqubana kweelastiki ize inxalenye yokukhanya isasazeke.Ukuphindaphinda kokukhanya okusasaziweyo kwahlukile kumaxesha okukhanya kwesiganeko, okwaziwa ngokuba yiRaman yokusasazwa.Ubunzulu beRaman bokusasaza bunxulumana nokwakheka kwemolekyuli, evumela uhlalutyo lwazo zombini ubunzulu kunye nobuninzi bayo ukumisela ubume bemolekyuli kunye nokwakheka ngokuchanekileyo.
Ngenxa yobuthathaka bophawu lweRaman kunye nokuphazamiseka rhoqo kwe-fluorescence, ukufumana i-Raman spectra ngexesha lobhaqo kunokuba ngumngeni.Ukufunyanwa okusebenzayo kophawu lweRaman kunzima ngokwenene.Ke ngoko, umphezulu ophuculweyo we-Raman spectroscopy unokunyusa kakhulu amandla okukhanya okusasazekileyo kweRaman, ukulungisa le miba.Umthetho-siseko osisiseko wobuchule ubandakanya ukubeka into eza kubhaqwa kumphezulu wesinyithi okhethekileyo, onjengesilivere okanye igolide.ukuze udale umphezulu orhabaxa, okwinqanaba le-nanometer, okhokelela kwisiphumo sokuphucula umphezulu.
Kwaboniswa ukuba i-Raman spectrum ye-marker platelet-derived growth factor (PDGF-BB) ibonise incopho ecacileyo kwi-1509 cm-1.Ngapha koko, kwafunyaniswa ukuba ubukho be-marker platelet-derived growth factor (PDGF-BB) kumchamo ehambelana ne-coronary artery stenosis.
Ngokusebenzisa iRaman spectroscopy kunye neteknoloji yokuphucula umphezulu, umhlalutyi wePDGF unokulinganisa ubukho bePDGF-BB kunye nophawu lwayo oluphezulu kumchamo.Oku kwenza ukuzimisela ukuba i-coronary arteries i-stenotic kunye neqondo le-stenosis, ngaloo ndlela inika isiseko sokuxilongwa kweklinikhi.
Imvelaphi yemveliso
Kwiminyaka yakutshanje, ukuxhaphaka kwesifo senhliziyo kuye kwanda ngokuthe ngcembe ngenxa yokutshintsha kwindlela yokutya kunye nendlela yokuphila, kunye nokuguga kwabantu.Izinga lokufa elinxulumene nesifo senhliziyo lihlala liphezulu ngendlela eyothusayo.Ngokwengxelo ye-China Cardiovascular Health and Disease Report 2022, izinga lokusweleka kwesifo sentliziyo phakathi kwabahlali basezidolophini baseTshayina liya kuba yi-126.91/100,000 kunye ne-135.88/100,000 kubahlali basemaphandleni ngo-2020. Eli nani liyenyuka ukususela ngo-2012 ngokunyuka okukhulu ezilalini.Kwi-2016, idlulile kwinqanaba leedolophini kwaye yaqhubeka inyuka kwi-2020. Okwangoku, i-coronary arteriography yindlela yokuqala yokuxilonga esetyenziswa kwizicwangciso zeklinikhi ukufumanisa isifo senhliziyo.Ngelixa kubhekiselwa kuyo "njengomgangatho wegolide" wokuxilongwa kwesifo senhliziyo, ukuhlaselwa kwayo kunye neendleko eziphezulu kukhokelele ekuphuhlisweni kwe-electrocardiography njengendlela yokuxilonga ngokuthe ngcembe.Nangona ukuxilongwa kwe-electrocardiogram (ECG) kulula, kulula, kwaye kungabizi, ukuxilongwa kakubi kunye nokushiywa kokuxilongwa kusengenzeka, kubangele ukuba kungathembeki kukuxilongwa kwekliniki yesifo senhliziyo.Ngoko ke, ukuphuhliswa kwendlela engabonakaliyo, enovelwano, kunye nethembekileyo yokufunyanwa kwangoko kunye nokukhawuleza kwesifo senhliziyo kubaluleke kakhulu.
I-Raman spectroscopy (i-SERS) eyomelezwe ngaphezulu komphezulu ifumene ukusetyenziswa ngokubanzi kwiinzululwazi zobomi zokubona ii-biomolecules kwiindawo eziphantsi kakhulu.Ngokomzekelo, uAlula et al.baye bakwazi ukubona amanqanaba emizuzu ye-creatinine kumchamo ngokusebenzisa i-SERS spectroscopy ene-photo catalytically modified silver nanoparticles eziqulethe izinto ezimagnetic.
Ngokufanayo, uMa et al.kusetyenziswe udibaniso oludityaniswe ngozibuthe lwe-nanoparticles kwi-SERS spectroscopy ukuveza ugxininiso oluphantsi kakhulu lwe-deoxyribonucleic acid (DNA) kwiibhaktheriya.
I-Platelet-derived growth factor-BB (PDGF-BB) idlala indima ephambili ekuphuhlisweni kwe-atherosclerosis ngokusebenzisa iindlela ezininzi kwaye inobudlelwane obusondeleyo kwi-coronary heart disease.I-Enzyme-linked immunosorbent assay (ELISA) yindlela ehamba phambili esetyenziswayo kwi-PDGF-BB uphando lwangoku lokufumanisa le proteni egazini.Ngokomzekelo, uYuran Zeng kunye noogxa bakhe bazimisele ukuxinana kweplasma ye-PDGF-BB ngokusebenzisa i-enzyme-linked immunosorbent assay kwaye baqonda ukuba i-PDGF-BB inegalelo elikhulu kwi-pathogenesis ye-carotid atherosclerosis.Kuphononongo lwethu, siqale sahlalutya imbonakalo ye-SERS yezisombululo zamanzi ezahlukeneyo zePDGF-BB ezinoxinzelelo oluphantsi kakhulu, sisebenzisa iqonga lethu le-785 nm Raman spectroscopy.Sifumene ukuba iincopho zeempawu kunye neRaman shift ye-1509 cm-1 zabelwa kwisisombululo se-aqueous ye-PDGF-BB.Ukongeza, siye safumanisa ukuba ezi ncopho zeempawu nazo zayanyaniswa nesisombululo esimanzi sePDGF-BB.
Inkampani yethu isebenzisana namaqela ophando eyunivesithi ukwenza uhlalutyo lwe-SERS spectroscopy kwiisampulu zomchamo ezingama-78 zizonke.Ezi zibandakanya iisampulu ze-20 ezivela kwizigulane ezenziwe utyando lwe-PCI, iisampulu ze-40 kwizigulane ezingazange zenziwe utyando lwe-PCI, kunye neesampuli ze-18 ezivela kubantu abaphilileyo.Sihlalutye ngokucokisekileyo imbonakalo ye-SERS yomchamo ngokudibanisa iincopho zeRaman kunye neRaman frequency shift ye-1509cm-1, edityaniswe ngokuthe ngqo kwi-PDGF-BB.Uphando lubonise ukuba iisampulu zomchamo wezigulane ezenze utyando lwe-PCI zazinophawu olubonakalayo lwe-1509cm-1, ngelixa le ncopho yayingekho kwiisampuli zomchamo zabantu abaphilileyo kunye nezigulane ezininzi ezingekho kwi-PCI.Ngexesha elifanayo, xa idatha yekliniki yesibhedlele ye-coronary angiography idibaniswe, kwagqitywa ukuba le ndlela yokufumanisa ihambelana kakuhle nokugqiba ukuba kukho ukuvaleka kwe-cardiovascular blockage ngaphezu kwe-70%.Ngaphezu koko, le ndlela inokuxilonga ngobuntununtunu kunye neenkcukacha ze-85% kunye ne-87% ngokulandelelana, iqondo lokuvaleka okukhulu kune-70% kwiimeko ze-coronary artery disease ngokuchonga iincopho ze-Raman ze-1509 cm-1.I-5%, ke, le ndlela ilindeleke ukuba ibe sisiseko esibalulekileyo sokwenza isigqibo sokuba ngaba abaguli abanesifo se-coronary artery bafuna i-PCI, inika ulwazi olunenzuzo kakhulu ekubhaqweni kwangaphambili kweemeko ezikrokrelekayo ze-coronary artery disease.
Ngenxa yale mvelaphi, inkampani yethu iphumeze iziphumo zophando lwethu lwangaphambili ngokuphehlelela iPlatelet Derived Growth Factor Analyzer.Esi sixhobo siya kuguqula kakhulu ukukhuthazwa kunye nokusetyenziswa ngokubanzi kokufunyanwa kwesifo senhliziyo sokuqala.Iya kuba negalelo elikhulu ekuphuculeni impilo ye-coronary heart e-China nakwihlabathi jikelele.
Uluhlu lweencwadi
[1] Huinan Yang, Chengxing Shen, Xiaoshu Cai et al.Uxilongo olungabonakaliyo kunye nolulindelekileyo lwesifo senhliziyo kunye nomchamo usebenzisa i-Raman spectroscopy eyomelezwe phezulu [J].Umhlalutyi, i-2018, i-143, i-2235-2242.
Amaphepha eParameter
| inombolo yemodeli | SEB-C100 |
| into yovavanyo | Ubunzulu bePlatelet-derived growth factor ebonakalisa incopho yomchamo |
| Iindlela zoVavanyo | automation |
| Ulwimi | IsiTshayina |
| Umgaqo-siseko wokufunyanwa | Raman spectroscopy |
| ujongano lonxibelelwano | I-Micro USB Port, Network Port, WiFi |
| iyaphinda | I-Coefficient yokwahluka kweziphumo zovavanyo ≤ 1.0% |
| iqondo lokuchaneka | Iziphumo zihambelana ngokusondeleyo kunye nemilinganiselo yesampula yemigangatho ehambelanayo. |
| uzinzo | I-Coefficient of variation ≤1.0% kwisampuli efanayo kwiiyure ze-8 zombane |
| Indlela yokurekhoda | Umboniso weLCD, ukugcinwa kwedatha yeFlashROM |
| ixesha lokubona | Ixesha lokuchongwa kwisampulu enye lingaphantsi kwemizuzwana ye-120 |
| Amandla okusebenza | iadaptha yamandla: AC 100V ~ 240V, 50/60Hz |
| imilinganiselo yangaphandle | 700mm(L)*560mm(W)*400mm(H) |
| ubunzima | Malunga nama-75kg |
| indawo yokusebenza | ubushushu bokusebenza: 10℃～30℃;ukufuma okuhambelanayo: ≤90%;uxinzelelo lomoya: 86kPa～106kPa |
| Indawo yothutho nokugcinwa kwayo | ubushushu bokusebenza: -40℃～55℃;ukufuma okuhambelanayo: ≤95%;uxinzelelo lomoya: 86kPa～106kPa |
